I was there in 2008 over Easter. The week before and the week after.It was definitely quieter, but most bars (if not all) were open. Plenty of ladies. So you wouldn't miss out on that.
However, if you were after a particular lady, she might not be there.
The Mall and a lot of other stores closed over the weekend too. So you might get caught if you need access to ATM. (IIRC the ATM @ ABC does not take all cards).
So nothing to do other than barhop and go back to your room for whatever.
Hope that helps.